Novel approaches for structural and functional analysis of the protein complex COG, a tether that controls intra-Golgi trafficking

Abstract:: Understanding the structure and dynamics of protein interaction networks is the greatest challenge of modern biology. This project is aimed at the development of an integrated approach for biophysical analysis, engineering, production, and structural analysis of multi-protein complexes. It will be applied to tethering complexes that contain up to 10 non-identical subunits and that control vesicular transport in eukaryotic cells. Data obtained in the project will elucidate the mechanisms of assembly and the structure of tethering complexes. The developed technologies should enable rapid progress in structure-function analysis of such important assemblies as the spliceosome, the nucleopore complex, and viruses
Grant type:: ARC Discovery Projects
Funded by:: Australian Research Council

The University of Queensland