The University of Queensland

Discovery and characterization of new classes of small regulatory RNAs in mammals (2009–2011)

Abstract:

The aims of this project are to characterise the RNAs that exist in the hitherto unexplored size range of 35-300 nt in developing mouse and human tissues, including mouse and human brain, the latter with particular emphasis on those derived from primate-specific Alu sequences, and to characterise the RNAs associated with RNA:DNA triplexes, chromatin-modifying complexes, transcription factors and RNA editing enzymes. The project will provide new insights into the mammalian transcriptome and the nature of RNAs associated with particular epigenetic pathways, with general importance to understanding genetic programming and gene regulation in higher organisms.

Grant type:

ARC Discovery Projects

Funded by:

Australian Research Council