AD A -induced cell death signalling by the p75 neurotrophin receptor. (2009–2011)

Abstract:
The amyloid peptide A is central to the cause of Alzheimer's disease. We have recently found that A can activate the cell death receptor p75NTR which is found in the nerve cells that die in Alzheimer's disease. This project will study whether this death pathway underpins the neuronal death associated with Alzheimer's disease. It will also determine the mechanism by which A activates p75NTR death signalling, and identify biochemical ways to prevent this from occurring.
Grant type:
NHMRC Project Grant
Researchers:
  • Professor and Deputy Head of School
    School of Biomedical Sciences
    Faculty of Medicine
    Professor
    Queensland Brain Institute
Funded by:
National Health and Medical Research Council