Understanding changes in the mammalian prenylome induced by statins and prenyltransferase inhibitors

Abstract:: Prenylation, the covalent attachment of isoprenoid lipids to proteins, is widespread in mammalian cells. Essential for a protein's normal function, it contributes to the progression of cancer and inflammation. We have developed a novel technology to identify all prenylated proteins in the cell. Aided by this method, we will analyse the effect of statins and anti-cancer drugs on protein prenylation. This will provide guidance in identifying a more effective clinical use for them.
Grant type:: NHMRC Project Grant
Funded by:: National Health and Medical Research Council