A novel marker of distressed neurons in the hypoxic brain: Regulation, function and potential clinical utility.

Abstract:: The brain is easily damaged by lack of oxygen (hypoxia). We have recently identified a novel protein called GLAST1b which is expressed in distressed neurons. This protein is a glutamate transporter. Glutamate is implicated as a toxic agent hypoxia. This study will investigate what regulates the expression of GLAST1b, what the consequences of expression are, and whether this marker can be developed as a diagnostic tool for identifying the presence of, and distribution of brain damage.
Grant type:: NHMRC Project Grant
Funded by:: National Health and Medical Research Council

The University of Queensland