GABA excitotoxicity, neuroprotection and the perinatal brain (2009–2011)
Approximately 3.5% of babies die each year from brain damage due to perinatal asphyxia, a shortage of oxygen to the developing brain. Babies that survive face lifelong neurological disabilities, placing enormous burden on health, social and economic resources. Current treatments are inadequate. We will examine what occurs when there is a shortage of oxygen to the developing brain and investigate pathways to hypoxic brain injury that offer opportunities for therapeutic intervention.