Novel polymeric microparticles for slow-release intrathecal delivery of analgesics (2010–2013)
Unrelieved pain is a large area of unmet medical need, adversely affecting the lives of millions of people worldwide. This project seeks to utilise innovative, green, polymer chemistry to develop bioerodable polymer particles to deliver the novel analgesic agent, Xen2174, into the spinal fluid in close proximity to its target receptors. The overall goal is to use this approach to produce prolonged periods of analgesia in the 10-30% of patients who do not obtain benefit from existing analgesic treatments delivered by less invasive routes. This bioerodable polymer technology has potential broad application to a wide range of drug treatments.