Novel polymeric microparticles for slow-release intrathecal delivery of analgesics (2010–2013)

Abstract:
Unrelieved pain is a large area of unmet medical need, adversely affecting the lives of millions of people worldwide. This project seeks to utilise innovative, green, polymer chemistry to develop bioerodable polymer particles to deliver the novel analgesic agent, Xen2174, into the spinal fluid in close proximity to its target receptors. The overall goal is to use this approach to produce prolonged periods of analgesia in the 10-30% of patients who do not obtain benefit from existing analgesic treatments delivered by less invasive routes. This bioerodable polymer technology has potential broad application to a wide range of drug treatments.
Grant type:
ARC Linkage Projects
Researchers:
  • Director, CIPDD
    UQ Centre for Clinical Research
    Faculty of Medicine
    Professor
    School of Pharmacy
    Faculty of Health and Behavioural Sciences
    Affiliate Professor
    Institute for Molecular Bioscience
  • Professorial Research Fellow
    Australian Institute for Bioengineering and Nanotechnology
    Affiliated Professor
    School of Chemistry and Molecular Biosciences
    Faculty of Science
    Affiliated Professor
    Centre for Advanced Imaging
  • Principal Research Fellow
    Centre for Advanced Imaging
    Affiliate PRF & Assoc Group Leader
    Australian Institute for Bioengineering and Nanotechnology
Funded by:
Australian Research Council