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To investigate the role of the protein kinase SMG-1 in the stress response (2010–2012)

Abstract:
A variety of mechanisms are available to cells to respond to DNA damage and other forms of stress. The protein kinase SMG-1 plays several roles in protecting cells against a variety of stresses. The overall aim is to employ a mutant mouse model of Smg-1 to investigate its role in the stress response. We have generated a knockout mutant mouse for SMG-1 and described an emerging phenotype in carriers of the mutant gene (Smg-1+/-).Furthermore this important resource will be used in strategic crosses with other mouse mutants in separate or overlapping pathways in the stress response. This project is significant in that it describes a novel approach to investigating the role of a specific protein involved in the stress response
Grant type:
ARC Discovery Projects
Researchers:

  • Dr Tara Roberts

    Honorary Senior Fellow
    UQ Centre for Clinical Research
    Faculty of Medicine
Funded by:
Australian Research Council