Functions of viral chemokine receptor homologues important for cytomegalovirus pathogenesis and latency (2010–2013)
Cytomegalovirus (CMV) causes life- threatening disease in babies, transplant recipients and HIV/AIDS patients. We will focus on a CMV gene that has been 'hijacked' from the host cell and enables the virus to switch on signalling molecules within infected cells. We will determine how these signals enable CMV to infect sites of the body that are critical for virus transmission and contribute to long-term virus persistence. Our results will provide new strategies for drugs against CMV.