The mechanism of ccbe1 function during lymphangiogenesis (2010–2012)

Abstract:
Tumours induce the regional growth of lymphatic vessels (in a process termed lymphangiogenesis) and then spread (a process termed metastasis) via lymphatic vessels and lymph nodes. Inhibiting lymphangiogenesis can inhibit metastasis. We have indentified a gene called ccbe1 that is essential for lymphangiogenesis during development. We aim to understand how this potential therapeutic target functions at the molecular level during lymphangiogenesis.
Grant type:
NHMRC Project Grant
Funded by:
National Health and Medical Research Council