The primary cilium in hedgehog signalling and disease (2010–2013)

Abstract:
Every mammalian cell has a single protrusion called the primary cilium. Recent studies in mice and humans have highlighted the importance of the primary cilium in disease states affecting the limb, kidney, skeleton, brain, eyes, ears and lungs, as well as obesity and diabetes. We have isolated a novel mouse with a defect in the machinery required for correct functioning of the primary cilium. This mouse has widespread abnormalities and will be used to elucidate the role of cilia in disease.
Grant type:
NHMRC Project Grant
Researchers:
  • Professorial Research Fellow - GL
    Institute for Molecular Bioscience
    Affiliate Professor
    School of Biomedical Sciences
    Faculty of Medicine
  • Senior Research Fellow
    Institute for Molecular Bioscience
  • Professor
    The University of Queensland Diamantina Institute
    Faculty of Medicine
    Affiliate Professor
    Institute for Molecular Bioscience
Funded by:
National Health and Medical Research Council