Cytoplasmic DNA as a danger signal for mammalian cells. (2010–2012)

Abstract:
DNA in mammalian cells is contained within a structure known as the nucleus. The presence of DNA outside the nucleus in the cytoplasm of the cells is a sure sign that something is wrong, and may indicate the presence of a viral invader. In this case the cell initiates anti-viral responses, including production of anti-viral proteins and death of the infected cell to stop replication of the virus. Lack of proper control of these responses may contribute to the autoimmune disease lupus.
Grant type:
NHMRC Project Grant
Researchers:
  • NHMRC Research Fellow
    School of Chemistry and Molecular Biosciences
    Faculty of Science
    Affiliate Research Fellow
    Institute for Molecular Bioscience
  • Honorary Fellow
    UQ Centre for Clinical Research
    Faculty of Medicine
  • Principal Research Fellow
    Institute for Molecular Bioscience
    Affiliate Associate Professor
    School of Chemistry and Molecular Biosciences
    Faculty of Science
Funded by:
National Health and Medical Research Council