Suppressor NKT cell trafficking to epithelial precancer (2010–2012)
The clinical use of the body's immune system to attack existing cancers has met with limited success. Cancer often avoids the immune response by setting up a suppressive environment locally at the tumour. Our study addresses one component of this local environment which involves recruitment of a special subset of suppressive white blood cells - NKT cells. We will establish if drugs can block their recruitment and prevent progression of the cancer.