The role of osteoclasts in the development of osteosarcoma metastases

Abstract:: Osteosarcoma is a cancer of the bone that afflicts children and young adults. Approximately 40-50% of patients will die of this disease due to the fatal complications of the disease spreading to the lungs. We believe that the reason this cancer moves from the bones to the lungs is because of the loss of a particular cell type in the bone. We will test this hypothesis formally in a number of independent models of osteosarcoma. If true, this will identify new ways to treat osteosarcoma.
Grant type:: Cancer Council Queensland
Funded by:: Cancer Council Queensland