Mechanisms of nerve fibre guidance by molecular gradients (2011–2013)
For the brain to function correctly its neurons must be connected correctly, and defects in brain wiring are known to underlie a number of cognitive disorders. An important type of cue that nerve fibres use to find their targets in the developing nervous system is guidance by molecular gradients. However little is known about how such gradients actually steer growing nerve fibres. In this proposal we will use a combination of experiments and mathematical modelling to uncover some of the fundamental computational principles underlying nerve fibre guidance.