Genetic analysis of lymphatic vascular development (2011–2015)

Abstract:
Lymphatic vessels form a vascular network responsible for tissue fluid homeostasis, immune cell transport and fatty acid metabolism. Altered lymphatic function can lead to lymphoedema, inflammatory disorders, obesity and cancer metastasis. Despite these major functions, the lymphatic system remains one of the most understudied organ systems in terms of its development. We have identified several zebrafish genetic mutants devoid of lymphatic vessels. One of these mutants led us to discovery a gene responsible for lymphatic vessel growth and lymphoedema in humans. We will characterise the function of this new gene and genetically map other new mutant genes to further our fundamental understanding of lymphatic vessel development in the embryo.
Grant type:
ARC Future Fellowships
Funded by:
Australian Research Council