Suppression of high-grade glioma by Nfib overexpression (2011–2012)
High-grade gliomas are the most aggressive forms of brain cancer, with only 50% of patients surviving their first year post-diagnosis. At present there is no cure for this disease and current treatments do not significantly delay tumour progression. Nuclear Factor One ¿B (Nfib) is a transcription factor that may prevent tumour growth through cellular differentiation. We will investigate the role of Nfib in the pathogenesis of high-grade glioma and its potential as a therapeutic target.