Retromer Directs Membrane Protein Trafficking within the Endosome (2012–2014)
Intracellular transport of biomolecules through the endosomal organelle is critical for normal cellular processes such as signaling and development. Defects in this fundamental process and its subversion by bacterial and viral pathogens lead to many different human diseases. Endosomal transport occurs within membrane domains and membrane tubules formed by Retromer and SNX-BAR proteins. This project aims to address this important problem by determining how Retromer and SNX-BAR proteins coordinate the selection of cargo and the formation of these dynamic endosomal membrane transport tubules.