The makings of maleness: Molecular and cellular functions of the Y-chromosomal sex-determining gene Sry (2012–2017)

Abstract:
Mammalian reproduction depends on the development of two sexes, which in turn hinges on whether testes develop under the influence of the Y-chromosomal sex-determining gene Sry. This project uses novel molecular, cellular and transgenic mouse strategies to expose genetic regulatory networks activated by Sry to direct testis development, as a model for molecular regulation of organ development more generally. Data generated in this project will inform the diagnosis and management of human developmental disorders, and provide a basis for innovative biotechnologies in pest management, wildlife conservation and livestock breeding.
Grant type:
ARC Discovery Projects
Researchers:
  • Professorial Research Fellow
    Institute for Molecular Bioscience
    Affiliate Professor
    School of Biomedical Sciences
    Faculty of Medicine
Funded by:
Australian Research Council