The molecular basis of ionic selectivity in nicotinic-type ion channel receptors.

Abstract:: The rapid transfer of chloride ions across cell membranes is essential for many physiological processes. The membrane proteins that facilitate the diffusion of selected ions across cell membranes are termed ion channels. These flux ions at amazingly high rates (millions/sec) while achieving almost perfect ionic selectivity. Here, we aim to elucidate the hitherto-unresolved mechanisms governing anion selectivity and flux rate in glycine and GABA receptor chloride channels. We anticipate being able to explain in molecular detail how chloride selectivity is achieved with such high fidelity while maintaining a high chloride flux rate. These findings will provide new insights into a wide variety of physiological and pathological processes.
Grant type:: ARC Discovery Projects
Funded by:: Australian Research Council

The University of Queensland