Understanding mechanisms and functions of evolutionary divergence in innate immune genes (2013–2016)

Abstract:
Multi-cellular organisms must survive in the face of microorganisms that have the potential to cause harm. Innate immunity provides the front line of defence against microbial challenge, but pathogens are able to overcome this system. This constant battle leads to co-evolution between host and pathogen, and hence differences in immune responses between host species. It is these species differences that are likely to be critical components of the immune response. This project will determine the functions of candidate species-specific innate immune response genes, as well as mechanisms driving these species differences. It will generate fundamental knowledge advancements in innate immune pathways important in host-pathogen interactions.
Grant type:
ARC Discovery Early Career Researcher Award
Funded by:
Australian Research Council