Role of senataxin in meiotic recombination and sex chromosome inactivation

Abstract:: The overall aim is to investigate the mechanism of action of a protein, senataxin, defective in a human genetic disorder. Disruption of the gene (Setx) specifying this protein leads to male infertility due to a defect in spermatogenesis. Mechanistic studies will be carried out with a mouse model to determine how senataxin functions to facilitate the process of RNA transcription termination and processing. The expected outcome is a greater understanding of how this protein functions in normal cellular processes. The project is significant in that it investigates the function of a protein for which little information is currently available.
Grant type:: ARC Discovery Projects
Funded by:: Australian Research Council

The University of Queensland