Development of a multicomponent delivery system for oligonucleotides (2013–2016)
This project introduces a novel delivery system for efficient in vitro delivery of nucleic acids to target cells. The proposed research aims to further improve current DNA/RNA-delivery systems, particularly cellular uptake, stability, targeting, and biological efficacy. The research aims to identify the optimal components for efficient delivery of a broad range of oligonucleotides. The approach proposed in this application is both novel and innovative, and will have a major contribution to our understanding of non-viral gene delivery mechanisms.