Conotoxins: Novel probes for ion channel structure and function (2002–2006)

Abstract:
Voltage-dependent and ligand-gated ion channels are intrinsic membrane proteins that play a central role in communication in excitable cells, particularly in the nervous system. The primary goals of this project are (i) to define at a molecular level, the structural and functional determinants of ion channel/conotoxin interactions and (ii) develop new probes that advance neurophysiological research. The diversity and distribution of ion channel types and subtypes being uncovered through the use of molecular biology and conotoxin probes presents an exciting opportunity for the future development of novel ion channel therapeutics.''
Grant type:
ARC Discovery Projects
Researchers:
  • Professorial Research Fellow
    Institute for Molecular Bioscience
    Affiliated Professor
    School of Chemistry and Molecular Biosciences
    Faculty of Science
  • ARC Laureate Fellow
    Institute for Molecular Bioscience
  • Professorial Research Fellow
    Institute for Molecular Bioscience
    Affiliate Professor
    School of Biomedical Sciences
    Faculty of Medicine
  • Professor
    Queensland Brain Institute
    Affiliate Research Fellow
    Institute for Molecular Bioscience
Funded by:
Australian Research Council