The Function Of Menin In Mammalian Development

Abstract:: This project aims to determine the role of a ubiquitous transcriptional co-regulator menin in mammalian development. Mice that lack menin through targeted deletion of the gene die during embryogenesis but the cause is unknown although is likely to be due to the abnormal expression of genes usually regulated by this factor. We will determine which genes are inappropriately expressed and responsible for the accompanying developmental defects. This knowledge will help us understand the process of development in mammals including birth defects in humans
Grant type:: ARC Discovery Projects
Funded by:: Australian Research Council