Common Recognition Elements In Protein Active Sites: Improving The Efficiencies Of Drug Discovery (2006–2008)
The pharmaceutical industry is currently plagued by increasing R&D costs matched with decreasing numbers of new drugs. There is a significant desire to improve the efficiencies of drug discovery. The issues facing drug discovery are not mechanical, there is significant capacity of synthesizing and screening large numbers of compounds, but are related to finding appropriate chemical deposits to mine. Biological activity of molecules appears to be clustered around certain classes of molecules, termed privileged substructures. This proposal describes an approach for understanding the principles behind the privileged substructure phenomena. Such principles can then be used to discover new and novel chemical deposits to aid drug discovery.