Cellular and molecular regulation of fetal ovarian development (2007–2009)
Normal development of the ovaries is critical for women's health and reproduction. Recent studies have shown that even the very earliest steps in ovarian development, occurring during fetal growth, can play a major part in predisposing to some of the most common and debilitating reproductive and endocrine disorders affecting Australian women. In this project we will take a systematic and comprehensive approach to exploring the mysteries of fetal ovary development, discovering what genes need to be activated and what cellular processes are required for normal ovary development and hence may play a part in ovarian diseases that manifest in later life. This work will offer new avenues for the prevention, diagnosis and treatment of ovarian disease and female infertility.