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Viral factors involved in flavivirus replication and virus-host interactions (2007–2010)

Abstract:
With our increased understanding of virus-host interactions it has become apparent that small, non-structural proteins and small RNAs of most viruses are vital for numerous, often multiple, functions in the viral life cycle. In the proposed project, we seek to gain a detailed understanding of the functions of small nonstructural protein NS2A and small abundant viral RNAs of medicaly important encephalitic flaviviruses, which have remained so far elusive and are at the cutting-edge in the research field. We anticipate that with a better understanding of the roles of these factors in flaviviral replication and pathogenesis, novel targets for antiviral therapies and/or molecular determinants for inclusion in candidate vaccines will be identified.
Grant type:
NHMRC Project Grant
Researchers:

  • Professor Alexander Khromykh

    Professor
    School of Chemistry and Molecular Biosciences
    Faculty of Science

  • Professor Paul Young

    Professor, Research Development
    Office of the Deputy Vice-Chancellor (Research and Innovation)
    Affiliate Professor
    Australian Institute for Bioengineering and Nanotechnology
Funded by:
National Health and Medical Research Council