Examining the role ASIC channels in pain through the development of subtype-specific ASIC channel modulators (2008–2010)

Abstract:
Acid sensing ion channels (ASICs) sense changes in acidity in the body. They are found throughout the body and may underlie nerve damage in stroke and some types of pain. ASICs also have many as yet unknown functions. A lack of selective tools to study ASICs is a major barrier to a complete understanding of what they do. This proposal aims to modify three animal toxins which block these receptors to make useful tools to study their function, in particular their role in sensing pain.
Grant type:
NHMRC Project Grant
Researchers:
  • Senior Lecturer
    School of Biomedical Sciences
    Faculty of Medicine
    Affiliate Senior Research Fellow
    Institute for Molecular Bioscience
  • Professorial Research Fellow
    Institute for Molecular Bioscience
    Affiliated Professor
    School of Chemistry and Molecular Biosciences
    Faculty of Science
  • Professorial Research Fellow
    Institute for Molecular Bioscience
    Affiliated Professor
    School of Chemistry and Molecular Biosciences
    Faculty of Science
Funded by:
National Health and Medical Research Council