The University of Queensland

Examining the role ASIC channels in pain through the development of subtype-specific ASIC channel modulators (2008–2010)

Abstract:

Acid sensing ion channels (ASICs) sense changes in acidity in the body. They are found throughout the body and may underlie nerve damage in stroke and some types of pain. ASICs also have many as yet unknown functions. A lack of selective tools to study ASICs is a major barrier to a complete understanding of what they do. This proposal aims to modify three animal toxins which block these receptors to make useful tools to study their function, in particular their role in sensing pain.

Grant type:

NHMRC Project Grant

Researchers:

• 

  Dr Lachlan Rash

  Associate Professor
  

  School of Biomedical Sciences

  Faculty of Medicine

• 

  Professor Glenn King

  Professorial Research Fellow - Grou
  

  Institute for Molecular Bioscience

Funded by:

National Health and Medical Research Council