Plant peptides as modulators of invertebrate neurohormone receptors

Abstract:: Naturally-occurring peptides are widely distributed in many plants but their biological role is often unclear. We isolated circular plant peptides (called cyclotides) that share similarities with the neuropeptide oxytocin, and acts on its receptor. This signaling system is important for reproduction, development, and behavior as well as water homeostasis. To elucidate the natural function of cyclotides we aim to characterize the pharmacological properties and biological effects of invertebrate receptors and their modulation by cyclotides. The notion that plants produce molecules to target invertebrate receptors is extremely appealing and will enhance our knowledge about fundamental biological processes of plant-animal ecology.
Grant type:: ARC Future Fellowships
Funded by:: Australian Research Council

The University of Queensland