NHMRC Research Fellowship: Pain Drugs from Venom Peptides (2015–2019)
Persistent pain is a costly and poorly managed disease. To address this major health burden, improved treatments are needed to meet this
significant unmet clinical need. We have identified venom peptides (conotoxins) from cone snails and spiders that either directly or indirectly (via G protein coupled receptors) inhibit voltage-gated sodium or calcium channels in pain pathways. Using recently established venomic
discovery capabilities, the goal is to discover venom peptides from cone snails and spiders that modulate sodium and calcium channels in peripheral pain and associated pathways and optimise these for clinical use.