Formation of the Chlamydial Inclusion Requires Host Trafficking Pathways (2015–2017)
Chlamydia are obligate intracellular pathogens responsible for a range of human and animal diseases. In
order to survive within the host cell, the pathogen pirates the host¿s membrane trafficking pathways to
engineer an intracellular niche called an inclusion. In addition to providing a permissive environment, this
strategy also shields the pathogen from the host¿s immune system. Using cellular and biochemical
approaches we will examine the membrane trafficking pathways hijacked by the pathogen and define the key
components of these pathways.