Defining the earliest events in lymphatic vasculature formation from veins (2015–2017)

Abstract:
Vascular system development is one of the earliest events that occurs in the embryo. Remarkably, the entire lymphatic vascular system forms from the embryos early veins. This project will define the earliest molecular and cellular changes essential to form an entire second vessel network from just a few precursor cells in the embryo. The study will utilize zebrafish and mouse embryos to greatly expand knowledge in the formation of this essential vertebrate tissue. Ultimately, this will provide new knowledge in stem and precursor cell differentiation, the evolution of complex organ systems and tissue formation. Outcomes may impact on future biotechnology in the areas of tissues engineering, stem cell differentiation and regeneration.
Grant type:
ARC Discovery Projects
Funded by:
Australian Research Council