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Unraveling autotransporter function in bacterial aggregates and biofilms (ARC Discovery Project administered by La Trobe University) (2015–2017)

Abstract:
Autotransporters are a large family of bacterial proteins that play a central role in pathogenesis. They promote the formation of cell clusters and biofilms, which are mechanisms for bacterial resistance to host immune factors and antibiotics. Currently, the precise mode of action of autotransporters is unknown. This project will examine the interplay between the structure and function of key autotransporter proteins. The outcomes of this research will establish how these proteins mediate aggregation and biofilm formation. It will also provide 3D structures of proteins that are strongly immunogenic and may represent targets for future vaccine design. Furthermore, this project will identify molecules that inhibit autotransporter function.
Grant type:
La Trobe University
Researchers:

  • Professor Mark Schembri

    Professorial Research Fellow & Grou
    Institute for Molecular Bioscience
    Professor
    School of Chemistry and Molecular Biosciences
    Faculty of Science
Funded by:
La Trobe University