Harnessing the potential of metals in biocatalysis (ARC Discovery Project administered by the Australian National University) (2015–2017)
We will use an integrated, multi-disciplinary approach to study the properties of a group of related but
functionally diverse enzymes, binuclear metallohydrolases (BMHs). These enzymes are of great relevance to
protein engineers aiming to produce potent agents for bioremediation and pharmacologists interested in
developing drugs. Elucidating and modulating the mode of action of BMHs is thus our main objective and will
provide essential information to fully exploit the potential of these enzymes for practical applications. In
particular, understanding how metal ions interact with BMHs and how this contributes to their reactivity is
crucial to optimally garner their biotechnological potential.