Control of selective microRNA release via exosomes and microvesicles (2016–2019)
Cells release genetic material including microRNAs in lipid membrane-enclosed vesicles (called exosomes and microvesicles) to alter neighbouring and distant cells. Recent research shows that the contents of these vesicles are regulated by cell state, however, the molecular mechanisms are not yet known. This project will investigate the hypothesis that changes in the RNA-binding protein composition of cholesterol-rich membranes mediate the selection of miRNA loaded in the vesicles. This fundamental knowledge will increase our understanding of mechanisms of disease because this mode of cell-to-cell communication is disrupted or hijacked in pathologies. Future translation in diverse applications may improve human, animal and plant health.