The role of X-chromosome inactivation in quantitative trait variation (2016–2019)
X-chromosome inactivation (XCI) is an important biological phenomenon but its effect on quantitative trait variation remains largely unknown. This project aims to develop novel statistical methods to estimate the X-linked genetic variance and the proportion that escapes XCI, and identify trait-associated genetic variants affected and not affected by XCI. The methods will be applied to large datasets from genome-wide association studies for a large number of traits (including gene expression traits). The unique methods and new knowledge will be of great significance to better understand the role of XCI in quantitative trait variation and gene expression in humans and animals.