Investigating the Molecular Mechanism of Synaptic Transmission. (2016–2019)
Neurons communicate with each other via the release of neurotransmitters at specialized structures known as synapses. Synaptic vesicle (SV) release from the presynaptic neuron is essential for this neuronal transmission, which drives all aspects of nervous system function, including behaviour and cognition. This project will investigate how key synaptic proteins and the interactions between them regulate spontaneous SV release. The proposal aims to reveal the molecular mechanism of both basal level regulation and the potentiation of spontaneous SV release, using a C. elegans model system, thereby increasing our understanding of synaptic function of the nervous system.