Engineered Spiky Silica Nanoparticles as Effective Immune Adjuvants by Activating Inflammasome and Enhancing Cellular Uptake (2017–2020)
Vaccination is a triumph of preventative healthcare in Australia and worldwide. Despite substantial advances in vaccine development, some of the most lethal diseases still lack effective vaccines. This project aims to generate a novel immune adjuvant with excellent safety to promote antigen immunity by rationally designing surface structure of nanomaterials. Successful completing of this project has great potential to bring new, safe and potent vaccines for some infectious disease and cancer.