Epitranscriptomic regulation of learning and memory (2017–2019)
Epitranscriptomics is an emerging field that investigates the vast number of modifications on RNA. There are over 100 distinct epitranscriptomic marks but most are still not characterised. This project aims to investigate the roles of m6A, the most prevalent internal modification in eukaryotic messenger RNA, in the mammalian brain. The adult brain contains a high level of m6A, which is highly reversible, strongly suggestive of a significant role of m6A in regulating the neuronal transcriptome during synaptic plasticity, the cellular basis of learning and memory. Through molecular and mouse behavioural assays, the outcomes of this study will provide new insights into the post-transcriptional regulation underlying learning and memory.