Molecular signals guiding dynamic cell movement during blood vessel growth (2017–2020)
Blood vessels form complex branched networks composed of arteries, capillaries and veins that supply oxygen and nutrients to all body tissues. The development and maintenance of blood vessels is dependent on the coordination of movement and adhesion between individual endothelial cells in the vessel wall, however the signals controlling these actions remain unknown. This project will utilise novel genetic models and cutting edge imaging techniques to unravel the precise way in which cells interact within the developing vessel sprout. These results will reveal how the vascular tree is formed during development, and have implications for the engineering of functional, vascularised organs in the biotech sector.