The potential of membranes - peptide engineering to modulate ion channels (2017–2021)
Sodium channels are involved in almost all aspects of human physiology. The ability to truly selectively inhibit individual sodium channel subtypes and to understand what drives peptides' ability to cross membranes represents a major achievement with endless opportunities to develop neuroscience research tools and technologies. This program aims to develop a platform technology necessary for the identification of novel and selective sodium channel inhibitors based on ultra-stable venom peptides with the ability to interact with and cross membranes. The development of this technology is of great scientific interest suitable for translation into new knowledge highly relevant to the biotechnology industry.