Properties of nanomaterials determine their disposal by liver cells (2017–2019)

Abstract:
Nanomaterials are now widely used in industrial, environmental, consumer and drug products, but how they impact on human health is poorly understood. It is critical to understand how nanomaterials in the body are handled by their main disposition organ, the liver, and impact the liver functions. We aim to characterise the spatiotemporal distribution of a set of nanomaterials with defined attributes in naïve and modified livers using state-of-the-art chemistry, imaging and biological methods. A key outcome will be to determine how the attributes of nanomaterials direct pathways for liver cell disposal. This work will build a novel paradigm that describes nanomaterial¿liver interactions at the cellular level.
Grant type:
ARC Discovery Projects
Researchers:
  • Snr Group Leader/VC Snr Res Fellow
    Australian Institute for Bioengineering and Nanotechnology
    Affiliate Principal Research Fellow
    Centre for Horticultural Science
    Queensland Alliance for Agriculture and Food Innovation
  • Prof Clinical Pharm & Therapeutics
    The University of Queensland Diamantina Institute
    Faculty of Medicine
Funded by:
Australian Research Council