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Ultrasensitive electrochemical biosensors (??)

Abstract:
This is a Synthetic Biology project aimed at the development of novel proteins that can convert biochemical cues into electronic signals. Using protein engineering we will produce redox protein-based OFF switches. We expect that the use of the OFF-switches (as opposed to ON switches) will significantly simplify biosensor design and create a new class of sensory architectures. Integration of OFF switch-based biosensors with an enzymatic signal amplification circuit is expected to yield ultrasensitive sensory systems with near real time response. The project addresses an urgent need for new technologies that enable collection of physiological and environmental information rapidly and at low cost outside of the specialised laboratories.
Grant type:
ARC Linkage Projects
Funded by:
Australian Research Council