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Probe-free biophysical force and torque measurements with optical tweezers (2018–2022)

Abstract:
This project aims to develop probe-free biophysical force and torque measurement methods based on optical tweezers to determine (a) forces on chromosomes during cell division and answer long standing questions on the character of these forces; (b) the forces exerted by cells while swimming, and map out how these forces are affected by their environment; and (c) the change in the elasticity of red blood cells over storage time. Studies of these biological systems are hampered by a lack of quantitative measurements. These accurate quantitative measurements will enable in-depth understanding of forces at work during cell division, properties of blood cells and sperm motility which could generate further research leading to health benefits.
Grant type:
ARC Discovery Projects
Researchers:

  • Professor Halina Rubinsztein-Dunlop

    Professor
    School of Mathematics and Physics
    Faculty of Science
    Affiliate Professor
    Australian Institute for Bioengineering and Nanotechnology

  • Dr Timo Nieminen

    Senior Lecturer
    School of Mathematics and Physics
    Faculty of Science
Funded by:
Australian Research Council