The molecular control of lymphatic vascular differentiation (2018–2019)

Abstract:
Vascular development is one of the earliest events that occurs in the embryo. Remarkably, the entire lymphatic vasculature forms from a pool of progenitor cells in early embryonic veins. We do not understand how a cell in a vein makes the fundamental decision to change state and produces a new and distinct vasculature. This project will define the early molecules that underpin this cellular decision and control lymphatic differentiation. We will use zebrafish embryos, new genomic datasets and novel tools to uncover the genetic control of this process. This will produce knowledge in cellular differentiation, organogenesis, vertebrate evolution and have implications in stem cell biology, tissue engineering, repair and regeneration.
Grant type:
ARC Discovery Projects
Funded by:
Australian Research Council