The epitranscripttomic landscape in ageing and dementia (2018)

Abstract:
This project aims to unravel the role of a novel signalling mechanism recently described at the RNA epigenetic level, in the process of normal ageing and in Alzheimer┬┐s disease (AD). The proposed research will provide the first transcriptome-wide maps of RNA modification in the normal versus pathological aged mouse brain. The outcomes of this study will provide novel molecular insights into the regulation of brain ageing and AD, which may underlie dementia-associated cognitive dysfunction.
Grant type:
UQ Early Career Researcher
Researchers:
  • ARC DECRA Research Fellow
    Clem Jones Centre for Ageing Dementia Research
    Queensland Brain Institute
Funded by:
University of Queensland