The epitranscripttomic landscape in ageing and dementia (2018)
This project aims to unravel the role of a novel signalling mechanism recently described at the RNA epigenetic level, in
the process of normal ageing and in Alzheimer¿s disease (AD). The proposed research will provide the first
transcriptome-wide maps of RNA modification in the normal versus pathological aged mouse brain. The outcomes of this
study will provide novel molecular insights into the regulation of brain ageing and AD, which may underlie
dementia-associated cognitive dysfunction.