A novel protein complex for Toll-like receptors tails pro-inflammatory responses (2018)
This project aims to characterise a complex of a new transmembrane adaptor SCIMP and CD11b. SCIMP has recently
been shown to modulate Toll-like receptor signaling producing only selected pro-inflammatory cytokines. To understand
the nature of this unique complex will underpin our efforts to find inhibitors as anti-inflammatory drugs. The outcomes will
include new knowledge about how specific cytokines are generated for tailored inflammatory responses in autoimmune
and inflammatory diseases.