Fine-scale resolution of genomes in natural microbial communities (ARC Discovery Project administered by the University of Technology Sydney) (2018–2021)

This project aims to develop advanced molecular and statistical techniques to precisely resolve the genomes of microbes in the environment. Microbes inhabit every niche on the planet and are fundamental to human and animal health, agriculture, and the environment. The proposed technology captures the 3D organisation of DNA sequences and integrates that data with statistical methods from machine learning to reconstruct genomes. We will demonstrate the technology by resolving the fine-scale population structure of Synechococcus in Australian waters. Synechococcus are one of Earth's most abundant microbes and are major contributors to the carbon cycle. We will also investigate the spread of antibiotic resistance genes in farm animals.
Grant type:
University of Technology Sydney
  • ARC Future Fellow
    School of Chemistry and Molecular Biosciences
    Faculty of Science
Funded by:
University of Technology Sydney