Enhanced electrochemical biosensing through electrohydrodynamic nanofluidics for cancer diagnostics (2018–2021)
The detection of cancer in its initial stage is difficult. An effective detection technology that could reliably analyse clinical
samples in the early stage of metastasis could potentially revolutionise cancer treatment. Electrochemical biosensors
hold great promise towards early cancer detection, but these sensors are inherently challenged by sensor fouling. In this
project, we propose a nanofluidic-enhanced in-situ electrochemical biosensor that shears off non-specific molecules and
simultaneously improves the target capture prior to electrochemical detection. The enhanced biosensor will be applied to
study the role of aberrant protein phosphorylation and glycosylation in cancer progression.